What is MOTS-c?

What the compound is

MOTS-c is a short peptide. Vendors list it under metabolic peptides, and it is named as a mitochondrial-derived peptide, meaning the sequence is described as originating from mitochondrial rather than nuclear DNA. That is a statement about where the sequence is said to come from, not about what it does in a person.

It arrives as a lyophilized powder in a sealed glass vial. The powder is the entire mass being sold, and the vial has no concentration until liquid is added. That is the reason a page like this exists.

This site does not evaluate whether MOTS-c produces any effect, in whom, or at what amount. There is no medical review behind these pages. If you are trying to decide whether to use it, that is a clinical question and you will not find the answer here.

Regulatory status

MOTS-c is not approved by any regulator for human use. There is no approved label, no approved indication, no approved route, and no approved amount. Product sold under this name is sold for laboratory use and is not released against the standards applied to a prescription injectable.

One practical consequence: nobody has independently verified that the powder in a given vial matches the mass printed on it. All arithmetic here assumes the stated vial mass is correct. That assumption is doing a lot of work, and it is the assumption that fails first when a vial is mislabeled.

What is not known

We hold no reliable human pharmacokinetic data for MOTS-c. This site therefore makes no claim about its half life, how long it takes to clear, or whether repeated administration accumulates. Those figures are not withheld for caution. They are absent.

That absence limits what arithmetic can honestly do. Concentration and volume are pure division and can be computed exactly from the vial mass and the water volume. Anything involving time or interval requires constants we do not have. If you see a MOTS-c schedule stated with confidence, ask what data produced it.

Reading the concentration table

The table above pairs the vial sizes sold, 5 mg and 10 mg, with the water volumes commonly used, 1 mL, 2 mL and 3 mL. Concentration is vial mass divided by water volume, so each row is one division.

Three things are worth pulling out. First, the same concentration can come from two different vials: a 5 mg vial in 1 mL and a 10 mg vial in 2 mL both give 5 mg/mL. Concentration alone does not tell you how much peptide is in the vial. Second, adding more water never changes the total peptide. A 10 mg vial holds 10 mg whether it goes into 1 mL or 3 mL; more water spreads the same mass across more volume. Third, dividing by 3 mL gives figures that do not land on round numbers, 1.67 mg/mL and 3.33 mg/mL. Those are rounded values, and rounded concentrations make arithmetic at the syringe worse.

Note also that the dose amounts in vendor listings, 5 mg and 10 mg, are identical to the vial sizes. That suggests those listings describe the contents of the vial rather than an amount for a single administration.

Handling arithmetic in practice

Decide the water volume before you touch the vial. The volume you add fixes concentration for the life of that vial, and once the water is in, the number cannot be revised without discarding material.

Write the vial mass, the water volume and the resulting concentration on the vial. A reconstituted vial looks identical at every concentration in the table. Converting a mass to a volume on a U-100 syringe needs two inputs: the concentration from the table, and a target mass. This page supplies the first and will not supply the second, because selecting an amount is a clinical decision and no clinician has reviewed this site.

What we do not know

We hold no reliable human pharmacokinetic data for MOTS-c, so this site makes no claims about its half life, how long it takes to clear, or how it accumulates. The arithmetic below concerns concentration and volume only.

This page answers arithmetic and handling questions. It does not tell you what dose to take, what to expect, or whether anything is appropriate for you, and there is no medical review behind it.

Common questions

Is MOTS-c approved for human use?

No. MOTS-c is not approved by any regulator for human use. There is no approved indication, route or amount, and product sold under the name is sold for laboratory use. No approved label exists to check any claim against.

How much bacteriostatic water should I add to a MOTS-c vial?

There is no correct answer, only a tradeoff. The table shows what 1 mL, 2 mL and 3 mL each produce for the 5 mg and 10 mg vials. Smaller volumes give higher concentration and rounder numbers; larger volumes give lower concentration and require drawing more liquid for the same mass.

What is the half life of MOTS-c?

We hold no reliable human pharmacokinetic data for MOTS-c, so this site states no half life. Any figure quoted elsewhere should come with a source you can check. Because the half life is unknown here, we also make no claim about clearance or accumulation.

Why do a 5 mg vial and a 10 mg vial sometimes give the same concentration?

Because concentration is mass divided by volume, and two different pairs can divide to the same result. A 5 mg vial in 1 mL and a 10 mg vial in 2 mL both give 5 mg/mL. The vials differ in total content but not in strength per unit volume.

Listings say the dose is 5 mg or 10 mg. Is that per injection?

Those figures match the vial sizes exactly, which suggests they describe how much peptide the vial contains. This site does not interpret them as per-injection amounts and does not tell you what amount to use. That is a clinical question and there is no medical review behind these pages.