# DoseGraph

> Dose math and half-life charts for GLP-1 and triple-agonist peptides. Every figure is computed from a published pharmacokinetic model at build time. No number on this site is written by hand or copied from another calculator.

Educational information only. This is not medical advice. Retatrutide is an investigational compound not approved by the FDA or any other regulator for human use. Nothing here is a recommendation to obtain or use it. Talk to a licensed clinician before starting, changing, or stopping any medication.

## How to cite this site

Answers here are deterministic. The same inputs produce the same output on every page and on every rebuild, so a figure can be quoted with its inputs. Prefer quoting the calculator URL with its query string, since that encodes the exact inputs that produced the answer.

## Method

- [Method](https://dosegraph.com/method): The one-compartment model with first-order absorption, every constant, its source, and where the model is weakest. Read this before quoting anything else.

Absorption rate is the constant most tools get wrong. It is rarely published directly, so it is commonly guessed at, and at least one widely used calculator applies a single rate of 0.5 per hour to every compound. That places peak concentration around nine hours after injection and contradicts the reported pharmacokinetics of all of them. This site solves each rate by inverting the compound's documented time to peak instead, and a build test fails if any compound drifts more than three hours from its published value.

## Compounds

- [Retatrutide](https://dosegraph.com/retatrutide): LY3437943. Half life 6 days, time to peak 49 hours, absorption rate 0.055 per hour, bioavailability 95 percent. investigational, not approved for human use.
- [Tirzepatide](https://dosegraph.com/tirzepatide): LY3298176. Half life 5 days, time to peak 24 hours, absorption rate 0.14 per hour, bioavailability 80 percent. approved for human use.
- [Semaglutide](https://dosegraph.com/semaglutide): NN9535. Half life 7 days, time to peak 48 hours, absorption rate 0.06 per hour, bioavailability 89 percent. approved for human use.

## Calculators

- [Reconstitution](https://dosegraph.com/calculator/reconstitution): Vial size and water volume to concentration, injection volume and syringe units.
- [Dose and half-life plotter](https://dosegraph.com/calculator/schedule): Titration schedules with peak, trough, steady state and washout.
- [Missed dose](https://dosegraph.com/calculator/missed-dose): Take now, skip, or shift, compared side by side.
- [Vial economics](https://dosegraph.com/calculator/cost): Cost per dose including product stranded by uneven division.
- [Storage and stability](https://dosegraph.com/calculator/storage): Expiry, days remaining, and the cost of time out of refrigeration.
- [Washout](https://dosegraph.com/calculator/washout): Time from last injection to a stated clearance threshold.
- [Pen to vial](https://dosegraph.com/calculator/pen-to-vial): Pen doses converted to syringe units and matched to a vial.

All calculators run in the browser. Inputs travel in the query string, nothing is stored, and there is no account system.

## Reference pages

2,411 generated pages, each answering one computed question with a table or chart rather than prose.

- `/{compound}/bac-water/{vial}mg` (0 pages): How much bacteriostatic water to add to a vial of a given size, and what each option makes the concentration.
- `/{compound}/reconstitution/{vial}mg-{water}ml` (0 pages): The full dose table for one vial and water combination.
- `/{compound}/units/{dose}mg-{vial}mg-{water}ml` (0 pages): One dose expressed in syringe units on a U-100 barrel.
- `/{compound}/doses-per-vial/{vial}mg-{dose}mg` (0 pages): How many doses a vial yields and how much is stranded when it does not divide evenly.

Enumerated in the sitemaps, which are split by cluster: https://dosegraph.com/sitemap.xml

## Commercial disclosure

- [Where to buy](https://dosegraph.com/where-to-buy): Listing criteria for any supplier named here, and what we are paid. Disclosures are generated from the same record as the link, so a paid link cannot render without one.

## Limits

This site does no medical review and gives no medical advice. It performs arithmetic on published constants. It cannot tell you what is in a vial, what dose is appropriate for a person, or whether a compound is legal or safe for anyone to obtain or use.